Organic St. John’s Wort (Hypericum perforatum) is an herb that has been widely used recently for the significant clinical research associated with relief of mild to moderate depression. It has been used since ancient times to treat a variety of ailments, such as ulcers, burns, wounds, abdominal pains and bacterial diseases. Certain properties of St. John’s Wort require caution due to the potential for the herb to influence the bioavailability of a wide range of conventional pharmaceuticals. At The Wellness Way we recognize the caution required when utilizing St. John’s Wort because of its potent effects on the liver and many physiological processes. A major liver pathway involving cytochrome P450 plays an important role in liver metabolism. This has significant effects on how medications affect the body, hormone levels, and many other metabolic processes that reflect liver function. This is why it is critical to understand specific Wellness Way tests to know when to best utilize St. John’s Wort or any other Wellness Way herb or supplement.